General Information

  • ID:  hor005164
  • Uniprot ID:  P22800(1-25)
  • Protein name:  Growth-blocking peptide
  • Gene name:  NA
  • Organism:  Cotesia kariyai (Parasitic wasp)
  • Family:  GBP/PSP1/paralytic peptide family
  • Source:  animal
  • Expression:  Hemolymph.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Cotesia (genus), Microgastrinae (subfamily), Braconidae (family), Ichneumonoidea (superfamily), Parasitoida (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005125 cytokine activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005615 extracellular space

Sequence Information

  • Sequence:  ENFSGGCVAGYMRTPDGRCKPTFYQ
  • Length:  25(1-25)
  • Propeptide:  ENFSGGCVAGYMRTPDGRCKPTFYQ
  • Signal peptide:  NA
  • Modification:  T25 Glutamine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It?prevents the onset of metamorphosis from larva to pupa in lepidopteran;this growth-blocking peptide has repressive activity against juvenile hormone esterase.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45857
  • Structure ID:  AF-P22800-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P22800-F1.pdbhor005164_AF2.pdbhor005164_ESM.pdb

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Physical Information

Mass: 321337 Formula: C120H178N34O37S3
Absent amino acids: HILW Common amino acids: G
pI: 8.21 Basic residues: 3
Polar residues: 12 Hydrophobic residues: 4
Hydrophobicity: -72 Boman Index: -5144
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 15.6
Instability Index: 2861.6 Extinction Coefficient cystines: 3105
Absorbance 280nm: 129.38

Literature

  • PubMed ID:  2022627
  • Title:  Structure of a growth-blocking peptide present in parasitized insect hemolymph.